MARCH 28, 12:00

AULA A1, CRM

LINK ZOOM

DESCRIPTION

Seminar “Effects of cell cycle variability on stochastic gene expression” by Rubén Pérez Carrasco | Imperial College London

ABSTRACT

Many models of stochastic gene expression do not incorporate a cell cycle description. I will show how this can be tackled analytically studying how mRNA fluctuations are influenced by DNA replication for a prescribed cell cycle duration stochasticity. Results show that omitting cell cycle details can introduce significant errors in the predicted mean and variance of gene expression for prokaryotic and eukaryotic organisms, reaching 25% error in the variance for mouse fibroblasts. Furthermore, we can derive a negative binomial approximation to the mRNA distribution, indicating that cell cycle stochasticity introduces similar fluctuations to bursty transcription. Finally, I will show how disregarding cell cycle stochasticity can introduce inference errors in transcription rates bigger than 10%.

Lecturer

Rubén Pérez Carrasco

Rubén Pérez Carrasco

Imperial College London

Dr. Perez-Carrasco interests focus on theoretical systems biology to understand how space, time, and precision are related at different scales in biology such as embryo development or synthetic biology.  To this end he is developing a systems biology mathematical framework that reveals insight into cell fate decisions employing  analytical and computational tools that make use of dynamical systems, stochastic processes, and Bayesian inference.

 

For inquiries about this event please contact the research programs coordinator Ms. Núria Hernández at nhernandez@crm.cat​​