Phone +34 93 586 8523
E-mail talarcon@crm.cat
Position Principal Investigator
Funding ICREA
Group Cancer Modelling Lab
Alarcon Cor, Tomas
Biosketch

About me

I studied Physics for my Bachelor degree and went on to earn a PhD in Physics (November 2000). Upon obtention of my PhD degree, I moved to Oxford where I took up a postdoc position at the Centre for Mathematical Biology, Mathematical Institute, where I started my research in modelling tumour growth working with Helen Byrne (Nottingham) and Philip Maini (Oxford), a subject that I still pursue. After three years in Oxford (from January 2001 to December 2003), I moved to London as a postdoc at the Bioinformatics Unit, University College London, with Karen Page (now in the Mathematics Department). There I worked in modelling tumour dormancy and the dynamics of cell surface receptors. In December 2006, after a short stay in Madrid, I joined the programme Complexity and Networks, lead by Henrik Jensen, at Imperial College, London as a postdoc to work in evolutionary processes under epigenetic regulation. In December 2009, I joined the Mathematical Biology group in the Basque Centre for Applied Mathematics (BCAM) as a BCAM researcher and Group Leader.

As of November 2010, I work at the Centre de Recerca Matematica (Bellaterra, Barcelona) where I lead the Computational & Mathematical Biology group.

My personal web site

Interests

Research Lines

Multiscale modelling of tumour growth and tumour-induced angiogenesis Evolutionary dynamics of populations with complex structure Mathematical modelling of the cell-cycle Stochastic modelling of receptor tyrosine kynases Tumour dormancy

Projects

Research grant as participant

1.- Grup de recerca en matematica col.laborativa del CRM (CRM research group on collaborative mathematics)funded by AGAUR (Catalan government).
GRANT NUMBER: 2014SGR1307
PI: Alvaro Corral (CRM)
DURATION: 3 year.
VALUE: 25800 Euros

2.- Kidney integration software: developing a new tool for diagnostic and decision making treatments for kidney tumours, funded by MINECO (Spanish government).
GRANT NUMBER: EUIN2013-51201
PI: Anna Messeguer (Vall d'Hebron Institute of Research)
DURATION: 2 year.
VALUE: 23000 Euros

Selected publications

These are the last publications but you can found more information regarding publications, including citation statistics on Google Scholar, Research ID, or ORCID 

 

Last publications in peer-reviewed journal


83.- D.Stepanova, H.M. Byrne, P.K. Maini, T. Alarcon. A multiscale model of complex endothelial cell dynamics in early angiogenesis. Posted in bioRxiv.


82.- M.O. Bernabeu, J. Kory, J.A. Grogan, B. Markelc, A. Beardo-Ricol, M. d'Avezac, J. Kaeppler, N. Daly, J. Hetherington, T. Krueger, P.K. Maini, J.M. Pitt-Francis, R.J. Muschel, T. Alarcon, H.M. Byrne. Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. Posted in bioRxiv.


81.- A.I. Rodriguez-Villarreal, L. Ortega-Tana, J. Cid, A. Hernendez-Machado, T. Alarcon, P. Miribel-Catala, J. Colomer-Farrarons. An integrated detection method for flow viscosity measurements in microdevices. IEEE Transactions on Biomedical Engineering. Accepted for publication (2020).


80.- E. Cuyas, S. Verdura, B. Martin-Castillo, T. Alarcon, R. Lupu, J. Bosch-Barrera, J.A. Menendez. Tumor-cell-intrinsic immunometabolism and precision nutrition in cancer immunotherapy. 12, 1757 (2020). doi: 10.3390/cancers12071757


79.- E. Cuyas, J. Gumizio, S. Verdura, J. Brunet, J. Bosch-Barrera, B. Martin-Castillo, T. Alarcon, J.A. Encinar, A. Martin, and J.A. Menendez. The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: A potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes. Aging.  12, 4794-4814 (2020). doi: 10.18632/aging.102887


78.- R.A. Barrio, T. Alarcon, A. Hernandez-Machado. The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature. PLoS One. 15, e0227562 (2020). doi: 10.1371/journal.pone.0227562


77.- J.A. Menendez, E. Cuyas, N. Folguera-Blasco, S. Verdura, B. Martin-Castillo, T. Alarcon. In silico clinical trials for anti-aging therapies. Aging. 11, 6591-6601 (2019). doi: 10.18632/aging.102180


76.- A.V. Ponce-Bobadilla, T. Carraro, H.M. Byrne, P.K. Maini, T. Alarcon. Age-structure can account for delayed logistic proliferation of scratch assays. Bull. Math. Biol. 81, 2706-2724 (2019). Preprint version available from bioRxiv