I studied Physics for my Bachelor degree and went on to earn a PhD in Physics (November 2000). Upon obtention of my PhD degree, I moved to Oxford where I took up a postdoc position at the Centre for Mathematical Biology, Mathematical Institute, where I started my research in modelling tumour growth working with Helen Byrne (Nottingham) and Philip Maini (Oxford), a subject that I still pursue. After three years in Oxford (from January 2001 to December 2003), I moved to London as a postdoc at the Bioinformatics Unit, University College London, with Karen Page (now in the Mathematics Department). There I worked in modelling tumour dormancy and the dynamics of cell surface receptors. In December 2006, after a short stay in Madrid, I joined the programme Complexity and Networks, lead by Henrik Jensen, at Imperial College, London as a postdoc to work in evolutionary processes under epigenetic regulation. In December 2009, I joined the Mathematical Biology group in the Basque Centre for Applied Mathematics (BCAM) as a BCAM researcher and Group Leader.
As of November 2010, I work at the Centre de Recerca Matematica (Bellaterra, Barcelona) where I lead the Computational & Mathematical Biology group.
Multiscale modelling of tumour growth and tumour-induced angiogenesis Evolutionary dynamics of populations with complex structure Mathematical modelling of the cell-cycle Stochastic modelling of receptor tyrosine kynases Tumour dormancy
Research grant as participant
1.- Grup de recerca en matematica col.laborativa del CRM (CRM research group on collaborative mathematics)funded by AGAUR (Catalan government).
GRANT NUMBER: 2014SGR1307
PI: Alvaro Corral (CRM)
DURATION: 3 year.
VALUE: 25800 Euros
2.- Kidney integration software: developing a new tool for diagnostic and decision making treatments for kidney tumours, funded by MINECO (Spanish government).
GRANT NUMBER: EUIN2013-51201
PI: Anna Messeguer (Vall d'Hebron Institute of Research)
DURATION: 2 year.
VALUE: 23000 Euros
Last publications in peer-reviewed journal
83.- D.Stepanova, H.M. Byrne, P.K. Maini, T. Alarcon. A multiscale model of complex endothelial cell dynamics in early angiogenesis. Posted in bioRxiv.
82.- M.O. Bernabeu, J. Kory, J.A. Grogan, B. Markelc, A. Beardo-Ricol, M. d'Avezac, J. Kaeppler, N. Daly, J. Hetherington, T. Krueger, P.K. Maini, J.M. Pitt-Francis, R.J. Muschel, T. Alarcon, H.M. Byrne. Abnormal morphology biases haematocrit distribution in tumour vasculature and contributes to heterogeneity in tissue oxygenation. Posted in bioRxiv.
81.- A.I. Rodriguez-Villarreal, L. Ortega-Tana, J. Cid, A. Hernendez-Machado, T. Alarcon, P. Miribel-Catala, J. Colomer-Farrarons. An integrated detection method for flow viscosity measurements in microdevices. IEEE Transactions on Biomedical Engineering. Accepted for publication (2020).
80.- E. Cuyas, S. Verdura, B. Martin-Castillo, T. Alarcon, R. Lupu, J. Bosch-Barrera, J.A. Menendez. Tumor-cell-intrinsic immunometabolism and precision nutrition in cancer immunotherapy. 12, 1757 (2020). doi: 10.3390/cancers12071757
79.- E. Cuyas, J. Gumizio, S. Verdura, J. Brunet, J. Bosch-Barrera, B. Martin-Castillo, T. Alarcon, J.A. Encinar, A. Martin, and J.A. Menendez. The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: A potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes. Aging. 12, 4794-4814 (2020). doi: 10.18632/aging.102887
78.- R.A. Barrio, T. Alarcon, A. Hernandez-Machado. The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature. PLoS One. 15, e0227562 (2020). doi: 10.1371/journal.pone.0227562
77.- J.A. Menendez, E. Cuyas, N. Folguera-Blasco, S. Verdura, B. Martin-Castillo, T. Alarcon. In silico clinical trials for anti-aging therapies. Aging. 11, 6591-6601 (2019). doi: 10.18632/aging.102180
76.- A.V. Ponce-Bobadilla, T. Carraro, H.M. Byrne, P.K. Maini, T. Alarcon. Age-structure can account for delayed logistic proliferation of scratch assays. Bull. Math. Biol. 81, 2706-2724 (2019). Preprint version available from bioRxiv