The computational neuroscience unit at the CRM was founded in 2012 and is made up of three Principal Investigators (Alex Roxin, Klaus Wimmer and Alex Hyafil) and their groups. The unit is an active member of a larger, Barcelona-wide Neuroscience community which includes theoretical, experimental and clinical groups located in a variety of university departments and research centers (www.barccsyn.org). Research in the computational neuroscience unit is largely focused on systems-level neuroscience. Broadly speaking, this involves investigating how large assemblies of interacting neurons give rise to animal and human behavior. Our approach is generally to combine computational modeling with data analysis.

Research Lines

The research focus in the group of Alex Roxin is on dynamical and network mechanisms in systems neuroscience. We model cognitive processes such as long-term memory formation and decision making, but also study the dynamical repertoire of neuronal networks more generally.

Research in the group of Klaus Wimmer focuses on the neural network dynamics underlying perceptual decision making and working memory, with the general aim of understanding the neural mechanisms underlying elementary cognitive functions.

The group led by Alex Hyafil has started in 2019, with an interest in understanding the core computations that underlie perception, decision-making and cognitive control in humans and mammals in general.

TEAM LEADERS

Toni Guillamon

UPC-CRM
antoni.guillamon@upc.edu

PERSONAL WEBSITE

Gemma Huguet

UPC-CRM
gemma.huguet@upc.edu

PERSONAL WEBSITE

Alexandre Hyafil

CRM
ahyafil@crm.cat

PERSONAL WEBSITE

Alex Roxin

CRM
aroxin@crm.cat

PERSONAL WEBSITE

Klaus Wimmer

CRM
kwimmer@crm.cat

PERSONAL WEBSITE

Lucía Arancibia
CRM

PhD Student

larancibia@crm.cat

IP: Klaus Wimmer

Sara Ibañez
CRM

Postdoctoral Researcher

sibañez@crm.cat

IP: Klaus Wimmer

Manuel Molano
CRM

Postdoctoral Researcher

mmolano@crm.cat

IP: Alexandre Hyafil

Personal Website ⇒

Nicolas Pollán
CRM

PhD Student

npollan@crm.cat

IP: Klaus Wimmer

Citlalli Vivar
CRM

PhD Student

cvivar@crm.cat

IP: Klaus Wimmer

Pan Ye
CRM

PhD Student

ypan@crm.cat

IP: Alex Roxin

PUBLICATIONS

 

Roxin, A. (2022). Notes on Meanfield Models for Spiking Networks for CIRM Course, March 2022.
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da Fonseca, M., Maffei, G., Moreno-Bote, R., & Hyafil, A. (2022). Mood and implicit confidence independently fluctuate at different time scales. Cognitive, Affective, & Behavioral Neuroscience, 1-20. LINK
Devalle, F., & Roxin, A. (2022). Fluctuation-driven plasticity allows for flexible rewiring of neuronal assemblies. arXiv preprint arXiv:2203.04641.
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Devalle, F., & Roxin, A. (2022). Network mechanisms underlying representational drift in area CA1 of hippocampus. bioRxiv. LINK
Baumard, N., Huillery, E., Hyafil, A., & Safra, L. (2022). The cultural evolution of love in literary history. Nature Human Behaviour6(4), 506-522. LINK
Hyafil, A., & Moriña, D. (2022). Analysis of the impact of lockdown on the reproduction number of the SARS-Cov-2 in Spain. Gaceta sanitaria35, 453-458. LINK
Esnaola-Acebes, Jose M., Alex Roxin, and Klaus Wimmer. Flexible integration of continuous sensory evidence in perceptual estimation tasks. Proceedings of the National Academy of Sciences 119.45 (2022): e2214441119. LINK
Scott, H., Wimmer, K., Pasternak, T., & Snyder, A. C. (2022). Altered Task Demands Lead to a Division of Labor for Sensory and Cognitive Processing in MT. bioRxiv, 2021-12. LINK
Hyafil, A., de la Rocha, J., Pericas, C., Katz, L. N., Huk, A. C., & Pillow, J. W. (2022). Temporal integration is a robust feature of perceptual decisions. bioRxiv. LINK
Prat-Ortega, G., Wimmer, K., Roxin, A., & de la Rocha, J. (2021). Flexible categorization in perceptual decision making. Nature communications, 12(1), 1-15. LINK
da Fonseca, M., Maffei, G., Moreno-Bote, R., & Hyafil, A. (2021). Emotional states and self-confidence independently fluctuate at different time scales. LINK
van Viegen, T., Akrami, A., Bonnen, K., DeWitt, E., Hyafil, A., Ledmyr, H., … & Peters, M. A. (2021). Neuromatch Academy: Teaching computational neuroscience with global accessibility. Trends in cognitive sciences25(7), 535-538.
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Hernández-Navarro, L., Hermoso-Mendizabal, A., Duque, D., de la Rocha, J., & Hyafil, A. (2021). Proactive and reactive accumulation-to-bound processes compete during perceptual decisions. Nature Communications12(1), 1-15. LINK
Esnaola-Acebes, Jose M., Alex Roxin, and Klaus Wimmer. Bump attractor dynamics underlying stimulus integration in perceptual estimation tasks. BioRxiv (2021). LINK
Hermoso-Mendizabal, A., Hyafil, A., Rueda-Orozco, P. E., Jaramillo, S., Robbe, D., & De la Rocha, J. (2020). Response outcomes gate the impact of expectations on perceptual decisions. Nature communications11(1), 1-13.
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Adam, V., & Hyafil, A. (2020). Non-linear regression models for behavioral and neural data analysis. arXiv preprint arXiv:2002.00920.
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Hernández-Navarro, L., Hermoso-Mendizabal, A., Duque, D., Hyafil, A., & de la Rocha, J. (2020). Sensory evidence integration and action initiation occur in parallel during perceptual decisions.
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Loyola-Navarro, R., Moënne-Loccoz, C., Vergara, R. C., Hyafil, A., Aboitiz, F., & Maldonado, P. E. (2020). Agency improves working memory and accelerates visual and attentional processing. BioRxiv.
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Malone, P. S., Eberhardt, S. P., Wimmer, K., Sprouse, C., Klein, R., Glomb, K., … & Riesenhuber, M. (2019). Neural mechanisms of vibrotactile categorization. Human brain mapping, 40(10), 3078-3090. LINK
Schustek, P., Hyafil, A., & Moreno-Bote, R. (2019). Human confidence judgments reflect reliability-based hierarchical integration of contextual information. Nature communications10(1), 1-15. LINK
Pietras, B., Devalle, F., Roxin, A., Daffertshofer, A., & Montbrió, E. (2019). Exact firing rate model reveals the differential effects of chemical versus electrical synapses in spiking networks. Physical Review E100(4), 042412. LINK
Roxin, Alex. Drift–diffusion models for multiple-alternative forced-choice decision making. The Journal of Mathematical Neuroscience 9.1 (2019): 1-23. LINK
Theodoni, P., Rovira, B., Wang, Y., & Roxin, A. (2018). Theta-modulation drives the emergence of connectivity patterns underlying replay in a network model of place cells. Elife7, e37388. LINK
Cernak, M., Asaei, A., & Hyafil, A. (2018). Cognitive speech coding: examining the impact of cognitive speech processing on speech compression. IEEE Signal Processing Magazine35(3), 97-109.
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Schmidt, H., Avitabile, D., Montbrió, E., & Roxin, A. (2018). Network mechanisms underlying the role of oscillations in cognitive tasks. PLoS computational biology14(9), e1006430.
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Esnaola-Acebes, J. M., Roxin, A., Avitabile, D., & Montbrió, E. (2017). Synchrony-induced modes of oscillation of a neural field model. Physical Review E96(5), 052407. LINK
Hyafil, A. (2017). Disharmony in neural oscillations. Journal of Neurophysiology118(1), 1-3.
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Jercog, D., Roxin, A., Bartho, P., Luczak, A., Compte, A., & de la Rocha, J. (2017). UP-DOWN cortical dynamics reflect state transitions in a bistable network. Elife6, e22425. LINK
Hyafil, A., & Moreno-Bote, R. (2017). Breaking down hierarchies of decision-making in primates. Elife6, e16650.
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Vegué, M., Perin, R., & Roxin, A. (2017). On the structure of cortical microcircuits inferred from small sample sizes. Journal of Neuroscience37(35), 8498-8510. LINK
Nykamp, D. Q., Friedman, D., Shaker, S., Shinn, M., Vella, M., Compte, A., & Roxin, A. (2017). Mean-field equations for neuronal networks with arbitrary degree distributions. Physical Review E95(4), 042323. LINK
Ramirez-Mahaluf, J. P., Roxin, A., Mayberg, H. S., & Compte, A. (2017). A computational model of major depression: the role of glutamate dysfunction on cingulo-frontal network dynamics. Cerebral Cortex27(1), 660-679.
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Roxin, A., & Compte, A. (2016). Oscillations in the bistable regime of neuronal networks. Physical Review E94(1), 012410. LINK
Wimmer, K., Ramon, M., Pasternak, T., & Compte, A. (2016). Transitions between multiband oscillatory patterns characterize memory-guided perceptual decisions in prefrontal circuits. Journal of Neuroscience36(2), 489-505. LINK
Sisan, T. B., Yi, T., Roxin, A., & Lichter, S. (2016). Liquid slip at the molecular scale. In Handbook of Nanophysics: Nanoparticles and Quantum Dots. CRC Press.
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Hyafil, A., & Koechlin, E. (2016). A neurocomputational model of human frontopolar cortex function. bioRxiv, 037150.
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Wimmer, K., Spinelli, P., & Pasternak, T. (2016). Prefrontal neurons represent motion signals from across the visual field but for memory-guided comparisons depend on neurons providing these signals. Journal of Neuroscience36(36), 9351-9364. LINK
Wimmer, K., Compte, A., Roxin, A., Peixoto, D., Renart, A., & De La Rocha, J. (2015). Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT. Nature communications6(1), 1-13. LINK
Baumard, N., Hyafil, A., Morris, I., & Boyer, P. (2015). Increased affluence explains the emergence of ascetic wisdoms and moralizing religions. Current Biology25(1), 10-15.
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Hyafil, A., Giraud, A. L., Fontolan, L., & Gutkin, B. (2015). Neural cross-frequency coupling: connecting architectures, mechanisms, and functions. Trends in neurosciences38(11), 725-740.
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Hyafil, A. (2015). Misidentifications of specific forms of cross-frequency coupling: three warnings. Frontiers in neuroscience9, 370.
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Montbrió, E., Pazó, D., & Roxin, A. (2015). Macroscopic description for networks of spiking neurons. Physical Review X5(2), 021028. LINK
Wimmer, K., Compte, A., Roxin, A., Peixoto, D., Renart, A., & De La Rocha, J. (2015). Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT. Nature communications6(1), 1-13. LINK
Hyafil, A., & Cernak, M. (2015). Neuromorphic based oscillatory device for incremental syllable boundary detection (No. REP_WORK). Idiap.
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Hyafil, A., Fontolan, L., Kabdebon, C., Gutkin, B., & Giraud, A. L. (2015). Speech encoding by coupled cortical theta and gamma oscillations. Elife4, e06213.
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Baumard, N., Hyafil, A., & Boyer, P. (2015). What changed during the axial age: Cognitive styles or reward systems?. Communicative & integrative biology8(5), e1046657.
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Wimmer, K., Nykamp, D. Q., Constantinidis, C., & Compte, A. (2014). Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory. Nature neuroscience17(3), 431-439. LINK
Roxin, A., & Fusi, S. (2013). Efficient partitioning of memory systems and its importance for memory consolidation. PLoS computational biology9(7), e1003146. LINK
Fontolan, L., Krupa, M., Hyafil, A., & Gutkin, B. (2013). Analytical insights on theta-gamma coupled neural oscillators. The Journal of Mathematical Neuroscience3(1), 1-20.
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Roxin, A., Brunel, N., Hansel, D., Mongillo, G., & van Vreeswijk, C. (2011). On the distribution of firing rates in networks of cortical neurons. Journal of Neuroscience31(45), 16217-16226. LINK
Roxin, A. (2011). The role of degree distribution in shaping the dynamics in networks of sparsely connected spiking neurons. Frontiers in computational neuroscience5, 8. LINK
Roxin, A., & Montbrió, E. (2011). How effective delays shape oscillatory dynamics in neuronal networks. Physica D: Nonlinear Phenomena240(3), 323-345. LINK
Hyafil, A., Gutkin, B., & Giraud, A. L. (2011). A theoretical exploration of speech/neural oscillation alignment for speech parsing. In Front. Hum. Neurosci. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI).
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Stimberg, M., Wimmer, K., Martin, R., Schwabe, L., Marino, J., Schummers, J., … & Obermayer, K. (2009). The operating regime of local computations in primary visual cortex. Cerebral Cortex19(9), 2166-2180. LINK
Hyafil, A., Summerfield, C., & Koechlin, E. (2009). Two mechanisms for task switching in the prefrontal cortex. Journal of Neuroscience29(16), 5135-5142.
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Wimmer, K., Stimberg, M., Martin, R., Schwabe, L., Mariño, J., Schummers, J., … & Obermayer, K. (2008). Dependence of orientation tuning on recurrent excitation and inhibition in a network model of V1. Advances in Neural Information Processing Systems21. LINK
Wimmer, K., Hildebrandt, K. J., Hennig, R. M., & Obermayer, K. (2008). Adaptation and selective information transmission in the cricket auditory neuron AN2. PLoS Computational Biology4(9), e1000182. LINK
Roxin, A., Hakim, V., & Brunel, N. (2008). The statistics of repeating patterns of cortical activity can be reproduced by a model network of stochastic binary neurons. Journal of neuroscience28(42), 10734-10745. LINK
Roxin, A., & Ledberg, A. (2008). Neurobiological models of two-choice decision making can be reduced to a one-dimensional nonlinear diffusion equation. PLoS Computational Biology4(3), e1000046. LINK
Martini, A., Roxin, A., Snurr, R. Q., Wang, Q., & Lichter, S. (2008). Molecular mechanisms of liquid slip. Journal of Fluid Mechanics600, 257-269. LINK
Hyafil, A. (2008). Du lien entre flexibilité cognitive et motivation dans le cortex préfrontal humain (Doctoral dissertation, Paris 6).
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Riecke, H., Roxin, A., Madruga, S., & Solla, S. A. (2007). Multiple attractors, long chaotic transients, and failure in small-world networks of excitable neurons. Chaos: An Interdisciplinary Journal of Nonlinear Science17(2), 026110. LINK
Schummers, J., Cronin, B., Wimmer, K., Stimberg, M., Martin, R., Obermayer, K. H., … & Sur, M. (2007). Dynamics of orientation tuning in cat V1 neurons depend on location within layers and orientation maps. Frontiers in neuroscience1, 11. LINK
Koechlin, E., & Hyafil, A. (2007). Anterior prefrontal function and the limits of human decision-making. Science318(5850), 594-598.
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Roxin, A., Brunel, N., & Hansel, D. (2006). Methods in Neuronal Modeling Methods in Neuronal Modeling, 1998. Progress of theoretical physics. Supplement161, 68-85. LINK
Jarsky, T., Roxin, A., Kath, W. L., & Spruston, N. (2005). Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nature neuroscience8(12), 1667-1676. LINK
Roxin, A., Brunel, N., & Hansel, D. (2005). Role of delays in shaping spatiotemporal dynamics of neuronal activity in large networks. Physical review letters94(23), 238103. LINK
Roxin, A., Riecke, H., & Solla, S. A. (2004). Self-sustained activity in a small-world network of excitable neurons. Physical review letters92(19), 198101. LINK
Lichter, S., Roxin, A., & Mandre, S. (2004). Mechanisms for liquid slip at solid surfaces. Physical review letters93(8), 086001. LINK
Roxin, A., & Riecke, H. (2002). Rotating convection in an anisotropic system. Physical Review E65(4), 046219. LINK
Roxin, A., & Riecke, H. (2001). Destabilization and localization of traveling waves by an advected field. Physica D: Nonlinear Phenomena156(1-2), 19-38. LINK
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